Roles of blood monocytes carrying TREM2^R47H mutation in pathogenesis of Alzheimer's disease and its therapeutic potential in APP/PS1 mice.

ABSTRACT:

Introduction

The triggering receptor expressed on myeloid cells 2 (TREM2) arginine-47-histidine (R47H) mutation is a significant risk for Alzheimer's disease (AD) with unclear mechanisms. Previous studies focused on microglial amyloid-β (Aβ) phagocytosis with less attention on the impact of TREM2^R47H mutation on blood monocytes.

Methods

Bone marrow transplantation (BMT) models were used to assess the contribution of blood monocytes carrying TREM2^R47H mutation to AD.

Results

Aβ phagocytosis was compromised in mouse monocytes carrying the TREM2^R47H mutation. Transplantation of bone marrow cells (BMCs) carrying TREM2^R47H mutation increased cerebral Aβ burden and aggravated AD-type pathologies. Moreover, the replacement of TREM2

SUBMITTER: Yu ZY 

PROVIDER: S-EPMC11848385 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature