Interocular retinal asymmetry and cognitive frailty: A prospective cohort study.

ABSTRACT:

Introduction

The retinal nerve fiber layer (RNFL) or ganglion cell-inner plexiform layer (GC-IPL) is associated with cognitive impairment. However, the relationship between retinal asymmetry and cognitive frailty (CF) remains unknown.

Methods

Two hundred twenty-two community-dwelling older adults were assessed starting in 2015 and underwent biennial cognitive and frailty evaluations until 2022. Retinal asymmetry was defined as the absolute interocular retinal difference. Generalized linear mixed models estimated the risk of CF over time.

Results

Among the participants, 158 completed the 4-year follow-up. Greater baseline GC-IPL asymmetry was associated with worsening CF over time (adjusted odds ratio = 1.06; 95% confidence interval [CI] = 1.03, 1.10), with handgrip st

SUBMITTER: Lee YS 

PROVIDER: S-EPMC11848388 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature