Polygenic risk discriminates Lewy body dementia from Alzheimer's disease.

ABSTRACT:

Introduction

Lewy body dementia (LBD) shares genetic risk factors with Alzheimer's disease (AD), including apolipoprotein E (APOE), but is distinguishable at the genome-wide level. Polygenic risk scores (PRS) may therefore improve diagnostic classification.

Methods

We assessed diagnostic classification using AD-PRS excluding APOE (AD-PRS_{no APOE}), APOE risk score (APOE-RS), and plasma phosphorylated tau 181 (p-tau181), in 83 participants with LBD, 27 with positron emission tomography amyloid beta (Aβ)positive mild cognitive impairment or AD (MCI+/AD), and 57 controls.

Results

Together AD-PRS_{no APOE} and APOE-RS performed similarly to p-tau181 in discriminating MCI+/AD from controls (area under the curve 76% vs. 79%) and LBD (7

SUBMITTER: McKeever A 

PROVIDER: S-EPMC11848393 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature