Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease.

ABSTRACT:

Introduction

Patterns of signal from tau positron emission tomography (tau-PET) confined to the medial temporal lobe (MTL) or extended into the neocortex may be relevant for Alzheimer's disease (AD) research if they are linked to differential biomarker levels and cognitive decline.

Methods

Visual assessment of Tau-PET [F-18]florquinitau (FQT) exams from 728 initially non-demented older adults yielded four uptake groups: tau-negative (T-), MTL-only (T+_MTL), neocortex-only (T+_Neo), or both (T+_MTL&Neo). Mixed effects models assessed group differences in retrospective cognitive and plasma pTau217 trajectories.

Results

T+_MTL&Neo was the most common T+ group (n = 97; 93% A+) and exhibited the sharpest worsening in cognitive and pT

SUBMITTER: Rea Reyes RE 

PROVIDER: S-EPMC11848396 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature