The pan-cancer analysis of LRG1 and its potential role in kidney renal clear cell carcinoma.

ABSTRACT: Leucine-rich α-2 glycoprotein 1 (LRG1) is a secreted glycoprotein implicated in various diseases, yet its role across multiple cancers remains insufficiently explored. Consequently, we conducted a comprehensive bioinformatics analysis, exploring LRG1 expression patterns, prognostic implications, and potential therapeutic associations in a pan-cancer context. Additionally, we collected gene expression and clinical data from patients with kidney renal clear cell carcinoma (KIRC) from TCGA, conducting gene set enrichment analysis (GSEA) and Cox proportional hazards regression analysis to explore the potential regulatory role of LRG1 in KIRC. Our study revealed that LRG1 expression is upregulated in 18 cancer types, with elevated levels correlating with poor prognostic outcomes in several canc

SUBMITTER: Lei Z 

PROVIDER: S-EPMC11848403 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature