Biological brain age and resilience in cognitively unimpaired 70-year-old individuals.

ABSTRACT:

Introduction

This study investigated the associations of brain age gap (BAG)-a biological marker of brain resilience-with life exposures, neuroimaging measures, biological processes, and cognitive function.

Methods

We derived BAG by subtracting predicted brain age from chronological age in 739 septuagenarians without dementia or neurological disorders. Robust linear regression models assessed BAG associations with life exposures, plasma inflammatory and metabolic biomarkers, magnetic resonance imaging, and cerebrospinal fluid biomarkers of neurodegeneration and vascular brain injury, and cognitive performance.

Results

Greater BAG (older-looking brains) was associated with physical inactivity, diabetes, and stroke, while prediabetes was related to lower BAG, that is, y

SUBMITTER: Marseglia A 

PROVIDER: S-EPMC11848408 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature