MiR124a-3p inhibitor alleviates AFB1-induced hepatoxicity via targeting chicken glucocorticoid receptor mRNA.

ABSTRACT: Glucocorticoid receptor (GR) plays crucial roles in various processes, including stress response, inflammatory response and toxin response, making it a therapeutic target for numerous diseases. microRNA (miRNA) can target and negatively regulate the expression of GR, thus interfering with its normal function. Aflatoxin B1 (AFB1) seriously affects poultry health and productivity, exhibiting hepatotoxicity and cytotoxicity. However, the expression of GR and GR-targeting miRNAs in poultry after AFB1 poisoning has not been studied. In this study, four-day-old broiler chicks were randomly divided into control group (CON) and AFB1 group (AFB1). After a 3-day pre-feed, the AFB1 group was given 0.25 mg/kg of AFB1 for 18 days. Hematoxylin and eosin (HE) staining revealed AFB1-induced hepatocyte dam

SUBMITTER: Zhao M 

PROVIDER: S-EPMC11848457 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature