Cognitive vulnerability to glucose fluctuations: A digital phenotype of neurodegeneration.

ABSTRACT:

Introduction

Cognition is reduced at low and high glucose, reflecting cognitive vulnerability to glucose (CVG) fluctuations. The impact of glucose fluctuations on the aging brain remains unclear. We examined whether CVG is associated with plasma biomarkers of Alzheimer's disease (AD) pathology and neurodegeneration.

Methods

Participants included N = 114 adults with type 1 diabetes assessed for processing speed and sustained attention using ecological momentary assessment (EMA) combined with continuous glucose monitoring (CGM). We characterized associations between CVG and amyloid beta (Aβ) 42/40, phosphorylated tau (p-tau) 181 and 217, neurofilament light chain, and glial fibrillary acidic protein.

Results

CVG was associated with all plasma biomarkers, except Aβ 42/40

SUBMITTER: Fonseca LM 

PROVIDER: S-EPMC11848531 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature