Amyloid is associated with accelerated atrophy in cognitively unimpaired individuals.

ABSTRACT:

Introduction

This study examined the association of longitudinal atrophy with baseline cerebrospinal fluid (CSF) amyloid beta (Aβ, A) and phosphorylated tau (p-tau, T) biomarkers (Aβ42/40, p-tau181) in 406 cognitively unimpaired (CU) individuals (6.670 years of follow-up on average, up to 13 imaging visits) to assess whether A+ is associated with Alzheimer's disease-like atrophy and whether this depends on p-tau181 levels.

Methods

An A-T- CU group free from abnormal neurodegeneration (N) was identified using a robust normative approach and used to model normal age-related atrophy via z-scoring. Linear mixed-effects models tested differences in longitudinal atrophy between A+ and A-T-N- individuals and between A/T subgroups.

Results

A+ was associated with worse

SUBMITTER: Stephenson HG 

PROVIDER: S-EPMC11848556 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature