Expanding the Functions of KHSRP Protein: Insights into DNA G-Quadruplex Binding.

ABSTRACT: KHSRP (KH-type splicing regulatory protein) is a multifunctional nucleic acid-binding protein that regulates various cellular processes, with critical roles in controlling gene expression. G-quadruplexes (G4s) are noncanonical nucleic acid structures involved in essential cellular activities, including gene expression, and are recognized as potential therapeutic targets in cancer. The biological functions of G4s are mediated by proteins making their formation highly dynamic within cells. Therefore, the recognition of G4s by specific proteins is crucial for modulating physiological and pathological pathways. Given the growing interest in DNA G4s, a deeper understanding of the proteins that interact with them and their molecular recognition is imperative. This study demonstrates that KHSRP b

SUBMITTER: Russomanno P 

PROVIDER: S-EPMC11848572 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature