Chirality-Induced Hydroxyapatite Manipulates Enantioselective Bone-Implant Interactions Toward Ameliorative Osteoporotic Osseointegration.

ABSTRACT: Inspired by the fundamental attribute of chirality in nature, chiral-engineered biomaterials now represent a groundbreaking frontier in biomedical fields. However, the integration of chirality within inorganic materials remains a critical challenge and developments of chirality-induced bionic bone implants are still in infancy. In this view, novel chiral hydroxyapatite (CHA) coated Ti alloys are successfully synthesized by a sophisticated chiral molecule-induced self-assembly method for the first time. The obtained samples are characterized by stereospecific L-/D-/Rac-chiral hierarchical morphology, nanotopography rough surfaces, improved hydrophilicity, and bioactivity. Following implantation into rat femoral condyle defects, the distinct stereospecific chiral hierarchical structures exhi

SUBMITTER: Yang L 

PROVIDER: S-EPMC11848601 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature