Plasma amyloid-β oligomerization tendency as a potential predictor for conversion from mild cognitive impairment to Alzheimer's dementia: Findings from the GMCII cohort.

ABSTRACT:

Introduction

This study aimed to explore the association between plasma amyloid-β oligomerization tendency (OAβ) and cognitive performance in Alzheimer's disease (AD) and determine its predictive value for outcomes of mild cognitive impairment (MCI).

Methods

Plasma from 727 subjects (286 AD, 260 MCI, and 181 controls) in a case registry was analyzed using the multimer detection system (MDS) to measure plasma OAβ.

Results

Elevated plasma OAβ was strongly correlated with multidomain cognitive performance in patients with MCI and AD. Patients with MCI with high baseline plasma OAβ demonstrated a higher risk of progressing to dementia (hazard ratio = 1.083, 95% confidence interval [CI] 1.032-1.137). Baseline plasma OAβ effectively predicted MCI-dementia conversion (area u

SUBMITTER: Xie Y 

PROVIDER: S-EPMC11848609 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature