BSA@IR780-loaded mesoporous polydopamine nanoparticles with enhanced photostability for multimodal imaging and photothermal therapy of tumors.

ABSTRACT: Multifunctional phototherapy that integrates diagnostic and therapeutic modalities holds the potential to revolutionize cancer treatment. The near-infrared cyanine dye IR780 is known for its high spatial resolution imaging capabilities. When conjugated with bovine serum albumin (BSA), it effectively mitigates common challenges such as photobleaching and fluorescence quenching, making it widely used in tumor imaging. However, its limited photothermal conversion efficiency hinders its broader application in tumor therapy. To overcome these limitations, this study presents the design and development of an imaging-guided multifunctional nanoplatform: mesoporous polydopamine (MPDA)-BSA@IR780. Our findings demonstrate that MPDA, as a carrier, significantly improves the photostability of BSA@IR78

SUBMITTER: Yang S 

PROVIDER: S-EPMC11848625 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature