Comparative effectiveness and safety of nifedipine and magnesium sulfate as treatment options for preterm birth: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Preterm birth (PTB) is a major cause of neonatal morbidity and mortality worldwide. Effective use of tocolytic agents may improve perinatal outcomes. This study aims to compare the effectiveness and safety of nifedipine and magnesium sulfate in the treatment of PTB.

Design

A systematic review and meta-analysis.

Data sources

China National Knowledge Infrastructure, China Science and Technology Journal Database, WanFang, PubMed, Embase, Web of Science and Cochrane were searched from inception to 1 December 2024.

Eligibility criteria

We included randomised controlled trials (RCTs) and cohort studies that compare the efficacy and safety of magnesium sulfate versus nifedipine in treating PTB.

Data extraction and synthesis

Two researchers independen

SUBMITTER: Fan J 

PROVIDER: S-EPMC11848690 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature