Epidemiological features of scrub typhus and molecular characteristics of Orientia tsutsugamushi in north-central Bangladesh.

ABSTRACT:

Objectives

Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi transmitted through trombiculid mites. This study aimed to clarify the prevalence and clinical features of scrub typhus and the molecular epidemiological characteristics of O. tsutsugamushi in north-central Bangladesh.

Methods

Blood samples were collected from patients with febrile illness at a single medical institution over a 1-year period. Using DNA samples extracted from blood, O. tsutsugamushi was identified by nested polymerase chain reaction targeting the outer membrane protein (47-kDa) gene. Phylogenetic analysis was performed based on the genes encoding a 56-kDa type-specific antigen (TSA) and trxA, along with genotyping by multilocus sequence typing (MLS

SUBMITTER: Nila SS 

PROVIDER: S-EPMC11848771 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature