Spatial mapping of dextran sodium sulphate-induced intestinal inflammation and its systemic effects.

ABSTRACT: Inflammatory bowel disease (IBD) is a multifactorial disease, and patients frequently experience extraintestinal manifestations affecting multiple sites. Causes of systemic inflammation remain poorly understood, but molecules originating from the intestine likely play a role, with microbial and host small molecules polarizing host immune cells towards a pro- or anti-inflammatory phenotype. Using the dextran sodium sulfate (DSS) mouse model, which mimics the disrupted barrier function, microbial dysbiosis, and immune cell dysregulation of IBD, we investigated metabolomic and phenotypic changes at intestinal and systemic sites. Using spatial biology approaches, we mapped the distribution and relative abundance of molecules and cell types across a range of tissues, revealing significant chang

SUBMITTER: Adams L 

PROVIDER: S-EPMC11848815 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature