Covalent Dynamic DNA Networks to Translate Multiple Inputs into Programmable Outputs.

ABSTRACT: Inspired by naturally occurring protein dimerization networks, in which a set of proteins interact with each other to achieve highly complex input-output behaviors, we demonstrate here a fully synthetic DNA-based dimerization network that enables highly programmable input-output computations. Our DNA-based dimerization network consists of DNA oligonucleotide monomers modified with reactive moieties that can covalently bond with each other to form dimer outputs in an all-to-all or many-to-many fashion. By designing DNA-based input strands that can specifically sequester DNA monomers, we can control the size of the reaction network and thus fine-tune the yield of each DNA dimer output in a predictable manner. Thanks to the programmability and specificity of DNA-DNA interactions, we show that

SUBMITTER: Brannetti S 

PROVIDER: S-EPMC11848822 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature