Renal Function Variability: An Independent Risk Factor for Graft Loss and Death following Kidney Transplantation.

ABSTRACT:

Background

Several studies have been performed to evaluate surrogate markers of long-term allograft function in renal transplant recipients. These include serum creatinine, estimated glomerular filtration rate (eGFR), slope of eGFR, and more recently eGFR variability. The aim of this study was to measure eGFR slope while assessing the variability of this slope and if high variability occurring at any time post-transplant was predictive of poorer long-term outcomes in a large cohort of kidney transplant recipients.

Methods

Adult solitary kidney transplant recipients transplanted between July 1, 2005 and July 31, 2015 were included. The primary outcome was time to graft loss, defined as return to chronic dialysis, retransplant, or death. Secondary outcomes were death-censored

SUBMITTER: Pilch NA 

PROVIDER: S-EPMC11848855 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature