Alichondrichlorin, a Novel Chlorohydrin-Containing Natural Product With Tumoral Cytotoxic Activity Isolated From the Planctomycetota Bacterium Alienimonas chondri LzC2^T.

ABSTRACT: To address the on-going need for chemical novelty and the limited information on Planctomycetota secondary metabolism, we focused on exploring the recently isolated marine planctomycetal strain Alienimonas chondri LzC2^T to uncover its potential production of novel compounds. This work contemplates the description of a large-scale cultivation study of strain LzC2^T, followed by metabolite extraction and compound isolation using chromatographic approaches, which resulted in the isolation of a novel molecule designated as alichondrichlorin. Structural elucidation of this new molecule was accomplished by a combination of high-resolution mass spectrometry and nuclear magnetic resonance. The molecule was additionally screened for anti-proliferative bioactivity against human

SUBMITTER: Vitorino IR 

PROVIDER: S-EPMC11848864 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature