Deregulation of Exosomal miR-17, miR-20a and TGFBR2 in Head and Neck Cancer Patients.

ABSTRACT: Introduction: Exosomes play significant roles in transferring cargo materials like proteins, RNAs (including miRNAs), and DNA. However, the role of serum exosome shuttled RNAs and miRNAs in head and neck cancer (HNC) remains unclear. This study assessed the diagnostic and prognostic significance of exosomal miR-17, miR-20a, and TGFBR2 in HNC patients. Methods: Exosomes were isolated, from 400 confirmed HNC patients and 400 healthy controls, and characterized by NTA, TEM, Immunolabelling, and ELISA. Quantitative PCR was used to check the expressions of exosomal molecules. Oxidative stress was also measured through ELISA in cancer patients and healthy controls. Results: Data analysis revealed significant dysregulation in the expressional levels of mi

SUBMITTER: Rizwan M 

PROVIDER: S-EPMC11848883 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature