Ultrasound-activated nano-oxygen sensitizer for sonodynamic-radiotherapy of esophageal cancer.

ABSTRACT: Background: owing to the intricate nature, variability, and persistent oxygen-deficient environment associated with esophageal cancer (EC) tissues, radiotherapy (RT) sometimes doesn't work as well because some cancer cells can resist the radiation to a certain extent. This can lead to the cancer coming back in the same spot or even making the treatment ineffective. The integration of RT with oxygenation strategies is a common approach in cancer treatment. The advent of oxygen-enhancing sonodynamic therapy (SDT), leveraging the cytotoxic effects of reactive oxygen species (ROS), has garnered significant attention as an innovative approach to inducing cell death. Methods: this study utilized nanobubbles (NBs) containing the acoustic sensitizer indocyanine green (ICG) to create

SUBMITTER: Liu J 

PROVIDER: S-EPMC11848934 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature