BMPR1a Is Required for the Optimal TGFβ1-Dependent CD207⁺ Langerhans Cell Differentiation and Limits Skin Inflammation through CD11c⁺ Cells.

ABSTRACT: The cytokine TGFβ1 induces epidermal Langerhans cell (LC) differentiation from human precursors, an effect mediated through BMPR1a/ALK3 signaling, as revealed from ectopic expression and receptor inhibition studies. Whether TGFβ1‒BMPR1a signaling is required for LC differentiation in vivo remained incompletely understood. We found that TGFβ1-deficient mice show defective perinatal expansion and differentiation of LCs. LCs can be identified within the normal healthy human epidermis by anti-BMPR1a immunohistology staining. Deletion of BMPR1a in all (vav⁺) hematopoietic cells revealed that BMPR1a is required for the efficient TGFβ1-dependent generation of CD207⁺ LC-like cells from CD11c⁺ intermediates in vitro. Similarly, BMPR1a was required for the optimal in

SUBMITTER: Hochgerner M 

PROVIDER: S-EPMC11849060 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature