LINE-1 methylation status and survival outcomes in colorectal cancer patients: A systematic review and meta-analysis.

ABSTRACT: Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. DNA hypomethylation, particularly of Long Interspersed Nuclear Element-1 (LINE-1) repetitive sequences, has been implicated in CRC development and progression. The purpose of this meta-analysis and systematic review was to evaluate the prognostic value of LINE-1 methylation level in patients with CRC. Relevant studies were identified through systematic database searches, and summary hazard ratios (HRs) with 95 % confidence intervals (CIs) were calculated for relations between LINE-1 hypomethylation and overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS). The current systematic review protocol was registered on International Prospective Register of Systematic Reviews (PROSPER

SUBMITTER: Bagheri A 

PROVIDER: S-EPMC11849065 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature