Two forced expiratory volume in 1 s trajectories with distinct prognoses in pulmonary Langerhans cell histiocytosis.

ABSTRACT:

Background

Lung function outcomes in pulmonary Langerhans cell histiocytosis (PLCH) patients are variable and difficult to predict. Our goal was to identify different forced expiratory volume in 1 s (FEV₁) trajectories in these patients during long-term follow-up.

Methods

All newly diagnosed adult PLCH patients seen between January 2004 and April 2018 were eligible for inclusion in our prospective cohort. The primary end-point was the identification of FEV₁ trajectories using a joint latent class model for longitudinal and time-to-event data. Internal validation was performed via bootstrapping.

Results

Among the 191 patients included (mean age of 39±12 years, 59% females, 96% current smokers), who were followed for a median of 5.1 years (i

SUBMITTER: Benattia A 

PROVIDER: S-EPMC11849112 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature