Antibacterial activity and impact on keratinocyte cell growth of Cutibacterium acnes bacteriophages in a Cutibacterium acnes IA₁- colonized keratinocyte model.

ABSTRACT: Acne is an inflammatory disease in which microbial disbalance is represented by an augmented population of phylotype IA₁ of Cutibacterium acnes. Various treatments for acne can cause side effects, and it has been reported that C. acnes is resistant to prescribed antibiotics. Phage therapy has been proposed as an alternative treatment for acne, given its species-specificity to kill bacteria, its relative innocuity, and its potential to manage antibiotic-resistant pathogens. Moreover, bacteriophages (phages) may modulate the microbiota and immune responses. Some studies have shown the potential use of phages in the treatment of acne. Nevertheless, the capacity to specifically reduce phylotype IA₁ and the effect of phage treatment on skin cells are poorly u

SUBMITTER: Farfan-Esquivel JC 

PROVIDER: S-EPMC11849128 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature