TCF1-LEF1 co-expression identifies a multipotent progenitor cell (T_H2-MPP) across human allergic diseases.

ABSTRACT: Repetitive exposure to antigen in chronic infection and cancer drives T cell exhaustion, limiting adaptive immunity. In contrast, aberrant, sustained T cell responses can persist over decades in human allergic disease. To understand these divergent outcomes, we employed bioinformatic, immunophenotyping and functional approaches with human diseased tissues, identifying an abundant population of type 2 helper T (T_H2) cells with co-expression of TCF7 and LEF1, and features of chronic activation. These cells, which we termed T_H2-multipotent progenitors (T_H2-MPP) could self-renew and differentiate into cytokine-producing effector cells, regulatory T (T_reg) cells and follicular helper T (T_FH) cells. Single-cell T-cell-receptor lineage tracin

SUBMITTER: Kratchmarov R 

PROVIDER: S-EPMC11849131 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature