Comparative toxicity study of three surface-modified titanium dioxide nanoparticles following subacute inhalation.

ABSTRACT:

Background

This study aimed to compare the toxic effects of three different titanium dioxide nanoparticles encoded in the European nanomaterial repository as NM-103 (rutile, hydrophobic), NM-104 (rutile, hydrophilic), and NM-105 (anatase/rutile, hydrophilic), suggesting different toxic potentials after uptake in the lungs. Wistar rats were exposed by nose-only inhalation to aerosol concentrations of 3, 12 and 48 mg/m³ for 4 weeks. This dosing scheme should induce non, partial and complete lung overload. The 4-week inhalation period was followed by 3-, 45- and 94-day exposure-free periods. Investigations according to the OECD 412 guideline were performed. Additional examinations, such as transmission electron microscopy and image analysis of tissue slides and cytospots, w

SUBMITTER: Schaudien D 

PROVIDER: S-EPMC11849269 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature