Secreted IgM deficiency alters the retinal landscape enhancing neurodegeneration associated with aging.

ABSTRACT:

Background

Maintenance of the retina, part of the central nervous system, and other structures in the eye is critical for vision preservation. Aging increases the prevalence of vision impairment, including glaucoma, macular degeneration, and diabetic retinopathy. The retina is primarily maintained by glial cells; however, recent literature suggests that lymphocytes may play a role in the homeostasis of central nervous system tissues. Natural antibodies are produced by B cells without infection or immunization and maintain tissue homeostasis. Here, we explored the potential role of natural immunoglobulin M (IgM) produced by B lymphocytes in maintaining retinal health during aging in mice.

Results

Our results indicate that the vitreous humor of both mice and humans contains Ig

SUBMITTER: Webster SE 

PROVIDER: S-EPMC11849284 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature