Metagenomic next-generation sequencing for etiological diagnosis of an unexpected rabies case with unclear exposure history.

ABSTRACT:

Background

Rabies is an acute and lethal zoonotic disease caused by the rabies virus (RABV). After onset, there are no effective drugs or treatment methods.

Case presentation

A 49-year-old female from Hefei, Anhui Province, China, presented to a local hospital with fever, pruritus, chest distress, and shortness of breath. During the consultation, the patient exhibited agitation and was later admitted to the intensive care unit (ICU) in the local hospital for endotracheal intubation and mechanical ventilation due to worsened agitation and dyspnea. Cerebrospinal fluid (CSF) and blood samples were collected and pathogenic microorganism identification was performed by culture and mNGS. However, all results were negative. In addition, the patient did not display typical rabies-sp

SUBMITTER: Wu J 

PROVIDER: S-EPMC11849319 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature