Malic enzyme 3 mediated the effects of malic acid on intestinal redox status and feed efficiency in broilers.

ABSTRACT:

Background

Intestinal oxidative stress serves as an endogenous host defense against the gut microbiota by increasing energy expenditure and therefore decreasing feed efficiency (FE). Several systems coordinately regulate redox balance, including the mitochondrial respiratory chain, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, and different antioxidants. However, it remains unclear which redox balance compartments in the intestine are crucial for determining FE.

Results

In this study, we first screened the key targets of different metabolites and redox balance-related gene expression in broiler ceca. We then constructed a mouse colitis model to explore malic acid (MA) ability to alleviate intestinal inflammation. We further used controlled release technology t

SUBMITTER: Jiang H 

PROVIDER: S-EPMC11849324 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature