Transposable elements may enhance antiviral resistance in HIV-1 elite controllers.

ABSTRACT:

Background

Less than 0.5% of people living with HIV-1 are elite controllers (ECs)-individuals who maintain undetectable plasma viremia without antiretroviral therapy, despite having replication-competent viral reservoirs. While EC CD4⁺ T cells have been investigated for gene expression signatures associated with HIV-1 resistance, the expression and regulatory activity of transposable elements (TEs) remain unexplored. TEs can directly impact host immune responses to pathogens, including HIV-1, suggesting their activities could contribute to HIV-1 elite control. To begin testing this hypothesis, we conduct a TE-centric analysis of public multi-omics data from ECs and other populations.

Results

We find the CD4⁺ T cell transcriptome and retrotranscriptome o

SUBMITTER: Singh M 

PROVIDER: S-EPMC11849351 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature