The role of insulin resistance and APOE genotype on blood-brain barrier integrity in Alzheimer's disease.

ABSTRACT:

Introduction

Growing evidence suggests a connection between insulin resistance and apolipoprotein E (APOE) genotype in Alzheimer's disease (AD) pathogenesis, but the mechanisms are unclear. We examined effects of insulin resistance and APOE genotype on blood-brain barrier (BBB) integrity in AD.

Methods

BBB integrity was measured in 196 biologically-confirmed non-diabetic patients with AD evaluating CSF/serum albumin ratio, kappa and lambda free light chains (FLCs). Insulin resistance was assessed using triglyceride-glucose index (TyG). The impact of TyG on BBB integrity, and its interaction with APOE genotypes, was analyzed using multivariate models.

Results

Sixty-four percent of patients with AD showed altered TyG, with the 21.8% classified as high TyG. TyG subgroups

SUBMITTER: Padovani A 

PROVIDER: S-EPMC11849409 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature