Collagen architecture and biomechanics of gracilis and adductor longus muscles from children with cerebral palsy.

ABSTRACT: Cerebral palsy (CP) describes some upper motoneuron disorders due to non-progressive disturbances occurring in the developing brain that cause progressive changes to muscle. While longer sarcomeres increase muscle stiffness in patients with CP compared to typically developing (TD) patients, changes in extracellular matrix (ECM) architecture can increase stiffness. Our goal was to investigate how changes in muscle and ECM architecture impact muscle stiffness, gait and joint function in CP. Gracilis and adductor longus biopsies were collected from children with CP undergoing tendon lengthening surgery for hamstring and hip adduction contractures, respectively. Gracilis biopsies were collected from TD patients undergoing anterior cruciate ligament reconstruction surgery with hamstring autogra

SUBMITTER: Wohlgemuth RP 

PROVIDER: S-EPMC11849552 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature