Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern Europeans.

ABSTRACT:

Background

The hypomorphic variant rs11209026-A in the IL23R gene provides significant protection against immune-related diseases in Europeans, notably inflammatory bowel diseases (IBD). Today, the A-allele occurs with an average frequency of 5% in Europe.

Methods

This study comprised 251 ancient genomes from Europe spanning over 14,000 years. In these samples, the investigation focused on admixture-informed analyses and selection scans of rs11209026-A and its haplotypes.

Findings

rs11209026-A was found at high frequencies in Anatolian Farmers (AF, 18%). AF later introduced the allele into the ancient European gene-pool. Subsequent admixture caused its frequency to decrease and formed the current southwest-to-northeast allele frequency cline in Europe. The geographic

SUBMITTER: Krause-Kyora B 

PROVIDER: S-EPMC11849592 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature