Effect of glucagon-like peptide-1 receptor agonists in osteoarthritis: A systematic review of pre-clinical and human studies.

ABSTRACT:

Objective

There is significant interest in the potential of glucagon-like peptide 1 receptor agonists (GLP-1A) to improve outcomes in osteoarthritis. We systematically reviewed the evidence from pre-clinical and human studies for effect of glucagon-like peptide 1 receptor agonists (GLP-1A) in osteoarthritis.

Method

Ovid Medline, Embase and CINAHL were searched (inception to November 2024) using MeSH terms and key words to identify studies examining the association between GLP-1A use and outcomes related to osteoarthritis. Risk of bias assessment and data extraction were conducted by three reviewers independently. Qualitative evidence synthesis was performed and prospectively registered on PROSPERO (CRD42024522782 and CRD42024522787).

Results

This systematic review inc

SUBMITTER: Cheng J 

PROVIDER: S-EPMC11849622 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature