Sex differences in epigenetic ageing for older people living with HIV.

ABSTRACT:

Background

HIV-1 infection impacts biological ageing, and epigenetic clocks highlight epigenetic age acceleration in people with HIV. Despite evidence indicating sex differences in clinical, immunological, and virological measures, females have been underrepresented in most HIV epigenetic studies. Hence, we generated a more representative epigenetic dataset to examine sex differences in epigenetic ageing and relationships to clinical phenotypes and proteomics.

Methods

We calculated first, second, and third-generation epigenetic ages using DNA methylation data in an observational cohort of 52 females and 106 males with HIV age 50 and over. We profiled plasma biomarkers with Olink high-throughput proteomics to test associations with epigenetic age acceleration. Survival was as

SUBMITTER: Johnston CD 

PROVIDER: S-EPMC11849644 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature