Dihydroquercetin attenuated Prevotella copri-caused intestinal injury by modulating gut microbiota and bile acids in weaned piglets.

ABSTRACT: Gut microbiota disruption during the weaning process is a significant factor of intestinal injury. Our previous studies have suggested that Prevotella may play a critical role in causing intestinal inflammation. This study aimed to clarify the impact of Prevotella copri on intestinal injury and the protecting effect by dihydroquercetin (DHQ) in weaned piglets. A total of 108 healthy Duroc × Landrace × Yorkshire weaned piglets, aged 21 d, were randomly allocated into 3 groups with 6 replicates and 6 piglets per replicate. The piglets were the following diets for 28 d: 1) a basal diet, 2) basal diet containing 1.0 × 10⁸ CFU/kg P. copri, 3) basal diet supplemented with 1.0 × 10⁸ CFU/kg P. copri and 100 mg/kg DHQ. Results showed that P.

SUBMITTER: Wang L 

PROVIDER: S-EPMC11849659 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature