Dissociable contributions of the amygdala and ventral hippocampus to stress-induced changes in defensive behavior.

ABSTRACT: Stress can have profound consequences on mental health. While much is known about the neural circuits supporting associative memories of stressful events, our understanding of the circuits underlying the non-associative impacts of stress, such as heightened stress sensitivity and anxiety-related behavior, is limited. Here, we demonstrate that the ventral hippocampus (vHC) and basolateral amygdala (BLA) support distinct non-associative behavioral changes following stress. Inhibiting stress-induced protein synthesis in the BLA blocked subsequent increases in stress sensitivity but not anxiety-related behaviors. Conversely, inhibiting stress-induced protein synthesis in the vHC blocked subsequent increases in anxiety-related behavior but not stress sensitivity. Inhibiting neuronal activity in

SUBMITTER: Pennington ZT 

PROVIDER: S-EPMC11849735 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature