Early life stress and pubertal predictors of subsequent substance use in a national diverse sample of adolescents: Sex and substance type matter.

ABSTRACT:

Background

Early life stress (ELS) increases the risk of substance use disorder (SUD) in adulthood. The pathway from ELS to SUD is hypothesized to be influenced by sex. We examine the impact of ELS on adolescent first substance use, a common precursor to adult SUDs, and test for sex differences in the relationship between ELS and risk of first use of alcohol, nicotine, and marijuana.

Methods

Individuals from the Adolescent Brain Cognitive Development study (ABCD; N = 8608 US children aged 9-10 at baseline) were assessed for multiple measures of ELS (Environmental, Family, Trauma), covariates (race/ethnicity, age in months at baseline, pubertal development score), and first substance use. Cox proportional hazards regression was performed for total population and stratified by

SUBMITTER: Donovan A 

PROVIDER: S-EPMC11849747 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature