Histomorphology of placentae of women with sickle cell disease during pregnancy - A case control study.

ABSTRACT:

Background

Sickle cell disease (SCD) is known to exert multifaceted effects on pregnancy, potentially influencing placental structure and function.

Aim

Our aim was to utilize stereology as a precise analytical tool to evaluate the histo-morphologic and functional changes in term placentae of women with SCD against those of non-SCD women.

Method

A case control study was conducted at the Korle-Bu Teaching Hospital's labour unit and included 38 pregnant women, comprising 19 cases and 19 controls. Placenta samples were paired and matched with gestational age and taken at term (38 weeks + 2 weeks). Tissue sections were prepared, stained with hematoxylin and eosin, and volume densities of syncytial knots, foetal capillaries, syncytial denuded areas, and intervillous spaces

SUBMITTER: Mumuni M 

PROVIDER: S-EPMC11849815 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature