Preoperative antihypertensives and hypotension during bladder tumor resection with oral 5-aminolevulinic acid administration.

ABSTRACT: 5-Aminolevulinic acid hydrochloride (5-ALA), a photodynamic diagnostic agent, visualizes bladder cancer. Previous research has indicated that preoperative intake of 5-ALA leads to a higher incidence of hypotension. Particularly in patients with hypertension, suggestions include discontinuing antihypertensive medications on the morning of surgery to prevent hypotension. However, the effects of antihypertensive drugs on hypotension in patients taking 5-ALA before surgery remains unexamined. We conducted a single-center observational study that included patients aged 20 and above who were regularly taking antihypertensives and underwent transurethral resection of bladder tumors (TURBT) after taking 5-ALA. Patients who took antihypertensives on the morning of surgery were defined as the contin

SUBMITTER: Kondo Y 

PROVIDER: S-EPMC11849823 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature