Delayed hepatic response and impaired cytokine dynamics in aged mice following burn injury: Implications for elderly patient care.

ABSTRACT:

Introduction

Burn injuries in elderly patients result in higher morbidity and mortality compared to younger individuals. This study investigates age-related differences in inflammatory hepatic responses to burn injuries.

Method

Young (8-10 weeks) and aged (20-21 months) female C57BL/6 mice were subjected to a 15% total body surface area burn or sham injury. Serum and liver samples collected at 3, 6-, 9-, 12-, and 24-hours post-injury were analyzed for serum amyloid A (SAA) levels, SAA1 and SAA2 hepatic gene expression, serum cytokines (IL-6, IL-1β, TNF-α, and IL-10), and hepatic STAT3 activation.

Results

Aged mice showed a delayed and dysregulated response. In young mice, SAA levels rose significantly at 6 hours postburn (5.09 ±  0.2-fold), while in aged mice, SAA inc

SUBMITTER: Muro I 

PROVIDER: S-EPMC11849828 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature