Exploratory study of serum protein biomarkers for sudden cardiac arrest using protein extension assay: A case-control study.

ABSTRACT:

Background

Biomarkers associated with the occurrence of sudden cardiac arrest (SCA) are not currently utilized in clinical practice. We aimed to identify novel protein biomarkers associated with sudden cardiac arrest (SCA) using proteomic profiling and evaluate their predictive power alongside traditional cardiovascular risk factors.

Methods

A total of 42 SCA patients with medical causes, aged ≤ 65 years and whose initial rhythm was shockable, and 42 age- and sex-matched controls were analyzed. The initial serum samples obtained after emergency department visits were used for SCA cases. Using a protein extension assay, we identified significant biomarkers through correlation analysis with SCA and extracted proteins with no or weak correlation with the initial lactate level a

SUBMITTER: Shin HY 

PROVIDER: S-EPMC11849859 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature