Association between serum neurofilament light chains and Life's Essential 8: A cross-sectional analysis.

ABSTRACT:

Background and aim

Serum neurofilament light chain (sNfL), a protein released into the bloodstream post-neuronal axonal damage, has been validated as a robust biomarker for a range of neurological and systemic diseases. Concurrently, Life's Essential 8 (LE8) comprises a holistic suite of health behaviors and metabolic markers that are essential for assessing and enhancing cardiovascular health. Nevertheless, the interrelation between LE8 and sNfL is not yet fully elucidated. This investigation seeks to evaluate the association between LE8 and sNfL within the framework of the National Health and Nutrition Examination Survey (NHANES).

Methods

According to data from the 2013-2014 NHANES, the study enrolled a total of 5262 participants aged between 20 and 75 years. We excluded 3

SUBMITTER: Wang T 

PROVIDER: S-EPMC11849891 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature