Increased dietary protein stimulates amino acid catabolism via the gut microbiota and secondary bile acid production.

ABSTRACT: Excess amino acids from a protein-rich diet are mainly catabolized in the liver. However, it is still unclear to what extent the gut microbiota may be involved in the mechanisms governing this catabolism. Therefore, the aim of this study was to investigate whether consumption of different dietary protein concentrations induces changes in the taxonomy of the gut microbiota, which may contribute to the regulation of hepatic amino acid catabolism. Consumption of a high-protein diet caused overexpression of HIF-1α in the colon and increase in mitochondrial activity, creating a more anaerobic environment that was associated with changes in the taxonomy of the gut microbiota promoting an increase in the synthesis of secondary bile acids, increased secretion of pancreatic glucagon. This effect wa

SUBMITTER: Tobon-Cornejo S 

PROVIDER: S-EPMC11849929 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature