Genetic inactivation of the β1 adrenergic receptor prevents cerebral cavernous malformations in zebrafish.

ABSTRACT: Previously, we showed that propranolol reduces experimental murine cerebral cavernous malformations (CCMs) and prevents embryonic caudal venous plexus (CVP) lesions in zebrafish that follow mosaic inactivation of ccm2 (Li et al., 2021). Because morpholino silencing of the β1 adrenergic receptor (adrb1) prevents the embryonic CVP lesion, we proposed that adrb1 plays a role in CCM pathogenesis. Here, we report that adrb1^-/- zebrafish exhibited 86% fewer CVP lesions and 87% reduction of CCM lesion volume relative to wild type brood mates at 2dpf and 8-10 weeks stage, respectively. Treatment with metoprolol, a β1 selective antagonist, yielded a similar reduction in CCM lesion volume. Adrb1^-/- zebrafish embryos exhibited reduced heart rat

SUBMITTER: Li W 

PROVIDER: S-EPMC11849999 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature