Altered hepatic metabolism mediates sepsis preventive effects of reduced glucose supply in infected preterm newborns.

ABSTRACT: Preterm infants are susceptible to neonatal sepsis, a syndrome of pro-inflammatory activity, organ damage, and altered metabolism following infection. Given the unique metabolic challenges and poor glucose regulatory capacity of preterm infants, their glucose intake during infection may have a high impact on the degree of metabolism dysregulation and organ damage. Using a preterm pig model of neonatal sepsis, we previously showed that a drastic restriction in glucose supply during infection protects against sepsis via suppression of glycolysis-induced inflammation, but results in severe hypoglycemia. Now we explored clinically relevant options for reducing glucose intake to decrease sepsis risk, without causing hypoglycemia and further explore the involvement of the liver in these protecti

SUBMITTER: Bæk O 

PROVIDER: S-EPMC11850001 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature