DNA methylome regulates virulence and metabolism in Pseudomonas syringae.

ABSTRACT: Bacterial pathogens employ epigenetic mechanisms, including DNA methylation, to adapt to environmental changes, and these mechanisms play important roles in various biological processes. Pseudomonas syringae is a model phytopathogenic bacterium, but its methylome is less well known than that of other species. In this study, we conducted single-molecule real-time sequencing to profile the DNA methylation landscape in three model pathovars of P. syringae. We identified one Type I restriction-modification system (HsdMSR), including the conserved sequence motif associated with N⁶-methyladenine (6mA). About 25-40% of the genes involved in DNA methylation were conserved in two or more of the strains, revealing the functional conservation of methylation in P. sy

SUBMITTER: Huang J 

PROVIDER: S-EPMC11850005 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature