Practical Utility of Serum Ammonia in Children With Acute Liver Failure: A Biomarker of Outcome.

ABSTRACT:

Background

Hyperammonemia is a recognized biochemical abnormality in acute liver failure (ALF). Our aim was to determine a cutoff value for serum ammonia in children with ALF to predict their outcomes while conventional UK liver transplant (LT) listing criteria were applied.

Methods

We reviewed and analyzed the data of 68 patients with ALF who presented to our center from January 2014 to December 2018; inherited defects of ammonia metabolism were excluded. Patients were divided into 3 groups: Gr 1, LT (30 patients); Gr2, native liver survival (27 patients); and Gr 3, mortality (11 patients).

Results

Highest ammonia levels during admission before intervention were higher in the LT and mortality group than in the native liver survival group (P = 0.011) with level

SUBMITTER: Abdullatif HM 

PROVIDER: S-EPMC11850043 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature