Puerarin Reversing Autophagy-Lysosomal Dysfunction via Acid Sphingomyelinase Inhibition in Cardiomyocytes.

ABSTRACT: Heart failure (HF) is a major cardiovascular disorder characterised by high prevalence and mortality rate. Recent studies have emphasised the role of autophagy in development and progression of HF. Dysfunctions in lysosomes and autophagic processes are closely associated with the aetiology of HF. Puerarin (PUE), a traditional Chinese medicine known for its antioxidant, anti-inflammatory and antiapoptotic properties, is widely used for the treatment of HF. However, the effectiveness of PUE in HF management via the modulation of autophagy requires further investigation. We used a mouse model of transverse aortic constriction to investigate protective effects of PUE on the autophagy-lysosomal pathway (ALP). We assessed heart function using echocardiography and performed histological staining

SUBMITTER: Li YP 

PROVIDER: S-EPMC11850092 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature